After the formation of the All Progressives Congress (APC) in 2013, Yemi was tasked, with other notable Nigerians, to design and produce a manifesto for the new political party. This culminated in the presentation of the “Roadmap to a New Nigeria”, a document published by APC as its manifesto if elected to power. The highlights of the Roadmap included a free schools meal plan, a conditional cash transfer to the 25 million poorest Nigerians if they enroll children in school and immunise them. There were also a number of programs designed to create economic opportunities for Nigeria’s massive youth population.

On 17 December 2014 the presidential candidate of the All Progressives Congress, retired General Muhammadu Buhari, announced Osinbajo as his running mate and vice-presidential candidate for the 2015 general elections.

On 31 March 2015 Buhari was confirmed by the Independent National Electoral Commission (INEC) as the winner of the presidential elections. Thus Osinbajo became the Vice President-elect of Nigeria. They were both sworn in on 29 May 2015.

Vice President

Yemi Osinbajo assumed office after taking the oath of office on 29 May 2015 at the Eagle Square, Abuja. As the Vice President of the Federal Republic of Nigeria, he is expected to oversee the economic planning team and report, as well as make recommendations, to the president who takes the final decision. Because of his legal background and antecedents as a Commissioner for Justice in Lagos state for eight years, many expect that he will contribute a great deal to the much needed reform of the judicial system at the national level. During the 2014/2015 campaigns of the All progressives Congress, Yemi Osinbajo held numerous town hall meetings across the country as against the popular rallies that many Nigerians and their politicians were used to. One of his campaign promises, which he has recently reiterated, was the plan to feed a school child a meal per day. Beyond feeding the school children, he has recently emphasized that this plan will create jobs (another campaign promise) for those who will make it happen.

Acting President

President Muhammadu Buhari wrote a written declaration on May 9 2017 to the president of the senate and house of representatives on his decision to embark on a medical trip, the letter was read on the 9 may 2017 at plenary of both houses, senate and house of representatives respectively. Vice president, Professor Yemi Osinbajo was conferred the acting president during president Buhari’s medical leave

He will be retiring from his current position as vice the president of Nigeria in the upcoming 2023 election.